Acetyl chloride → HCID 71062072, compound

HRID 2275320Notes

Reaction equation

HRID 2275320 reaction equation
[Cl-].[Al+3].[Cl-].[Cl-].[CH2:5]([N:7]1[C:26]2[C:14](=[CH:15][C:16]3[C:17]([CH2:28][CH3:29])([CH3:27])[C:18]4[CH:19]=[CH:20][CH:21]=[CH:22][C:23]=4[C:24]=3[CH:25]=2)[C:13]2[C:8]1=[CH:9][CH:10]=[CH:11][CH:12]=2)[CH3:6].[C:30](Cl)(=[O:32])[CH3:31]>ClCCl>[C:30]([C:21]1[CH:20]=[CH:19][C:18]2[C:17]([CH2:28][CH3:29])([CH3:27])[C:16]3[CH:15]=[C:14]4[C:13]5[C:8]([N:7]([CH2:5][CH3:6])[C:26]4=[CH:25][C:24]=3[C:23]=2[CH:22]=1)=[CH:9][CH:10]=[CH:11][CH:12]=5)(=[O:32])[CH3:31]

Participants

5

Reactant 3

HCID 6367Acetyl chlorideHCID 6451240Aluminum(III) ChlorideHCID 71085576HCID 71085576, compound

Product 1

HCID 71062072HCID 71062072, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

Aluminum chloride (3.43 g, 25.6 mmol) was slowly added into a dichloromethane solution (80 mL) in which were dissolved 6,12-diethyl-12-methyl-6,12-dihydro-6-aza-indeno[1,2-b]fluorene (5.95 g, 20.0 mmol) and acetyl chloride (1.83 mL, 25.7 mmol) at 0° C. under nitrogen atmosphere. After stirring at room temperature overnight, the reaction mixture was poured into ice-water. The product was extracted twice with dichloromethane. The combined organic layer was washed with brine, and dried over MgSO4. The dichloromethane was removed under high vacuum and the product thus obtained was used for the next step without further purification.

Workup

  1. extractionThe product was extracted twice with dichloromethane
  2. washThe combined organic layer was washed with brine
  3. dry with materialdried over MgSO4
  4. customThe dichloromethane was removed under high vacuum
  5. customthe product thus obtained
  6. customwas used for the next step without further purification

Sources & evidence

ORD record
ord-506660b00c084e81b95ed4172deab731
Source dataset
uspto-grants-2015_09
Patent number
US09127017B2

Reaction notes

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