反应详情

(2R,4R)-tert-Butyl 2-(3-fluorophenyl)-4-hydroxypyrrolidine-1-carboxylate (1.4 g, 4.98 mmol) and Dess-Martin periodinane (2.53 g, 5.97 mmol) were mixed in 50 mL DCM and stirred at ambient temperature overnight. For workup, 20 mL 1N NaOH was added to reaction, and stirred for 30 minutes, followed by addition of 20 mL brine. The reaction mixture was extracted with several portions of DCM. The combined organic extracts were filtered through a Phase Separator filter paper, concentrated, and purified by reverse phase chromatography, eluting with 20-70% acetonitrile/water to yield the product as yellow oil (600 mg, 43% yield.)

1. stirringstirred for 30 minutes
2. extractionThe reaction mixture was extracted with several portions of DCM
3. filtrationThe combined organic extracts were filtered through a Phase Separator
4. filtrationfilter paper
5. concentrationconcentrated
6. custompurified by reverse phase chromatography
7. washeluting with 20-70% acetonitrile/water