Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | Methyl iodide | HCID 6328 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 2-Chloro-3-pyridinol | HCID 81136 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | 2-Chloro-3-methoxypyridine | HCID 104252 | — |
Reaction Steps
To a solution of 2-chloro-pyridin-3-ol (100 g) in DMSO (1 L) was added potassium carbonate (320 g). Methyliodide was added dropwise. The reaction mixture was heated to 50° C. overnight. The reaction mixture poured into water and extracted with ethyl acetate. The organic phase was washed with brine, dried over Na2SO4, filtered and concentrated to give the desired compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09127007B2 |
|---|
| Source dataset | uspto-grants-2015_09 |
|---|
| ORD ID | ord-1462db7cc41c4cda840facf39912818c |
|---|
| Source note | uspto-grants-2015_09 |
|---|
