Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Water | HCID 962 | — |
| Reactant | 2-Chloro-3-methoxypyridine | HCID 104252 | — |
| Reactant | Sodium Methoxide | HCID 10942334 | — |
| Solvent | Dimethyl Sulfoxide | HCID 679 | — |
| Product | 2,3-Dimethoxypyridine | HCID 4657809 | — |
Reaction Steps
To a solution of 2-chloro-3-methoxy-pyridine (110 g) in DMSO (1 L) was added sodium methoxide (124 g). The reaction mixture was heated to 80° C. overnight. The reaction mixture was poured into 3 L water and extracted with ethyl acetate. The organic phase was washed with brine, dried over Na2SO4, filtered and concentrated to give the crude product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09127007B2 |
|---|
| Source dataset | uspto-grants-2015_09 |
|---|
| ORD ID | ord-f69f43d01caf4a328301d681da554e59 |
|---|
| Source note | uspto-grants-2015_09 |
|---|
