4-Carboxy-1,2,3-triazole → HCID 178467783, compound

HRID 2275491Notes

Reaction equation

HRID 2275491 reaction equation
[NH:1]1[CH:5]=[C:4]([C:6]([OH:8])=O)[N:3]=[N:2]1.[NH2:9][C@H:10]([CH2:21][C:22]1[CH:27]=[CH:26][C:25]([C:28]2[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=2)=[CH:24][CH:23]=1)[CH2:11][C@:12]([CH2:17][O:18][CH2:19][CH3:20])([CH3:16])[C:13]([OH:15])=[O:14]>>[C:25]1([C:28]2[CH:29]=[CH:30][CH:31]=[CH:32][CH:33]=2)[CH:24]=[CH:23][C:22]([CH2:21][C@@H:10]([NH:9][C:6]([C:4]2[N:3]=[N:2][NH:1][CH:5]=2)=[O:8])[CH2:11][C@:12]([CH2:17][O:18][CH2:19][CH3:20])([CH3:16])[C:13]([OH:15])=[O:14])=[CH:27][CH:26]=1

Participants

3

Reactant 2

HCID 1401204-Carboxy-1,2,3-triazoleHCID 89964511HCID 89964511, compound

Product 1

HCID 178467783HCID 178467783, compound

Procedure

1H-[1,2,3]Triazole-4-carboxylic acid and (2S,4R)-4-amino-5-biphenyl-4-yl-2-ethoxymethyl-2-methylpentanoic acid were reacted as described herein to yield the title compound (0.8 mg). MS m/z [M+H]+ calc'd for C24H28N4O4, 437.21. found 437.2.

Sources & evidence

ORD record
ord-8247b8dbbced4bed884a7527fb3ecb3f
Source dataset
uspto-grants-2015_09
Patent number
US09126956B2

Reaction notes

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