HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → HCID 73052913, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | HCID 89964351 | HCID 89964351 | — |
| Reactant | HCID 89964407 | HCID 89964407 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 73052913 | HCID 73052913 | 8.3% |
Reaction Steps
1-Methoxy-1H-[1,2,3]triazole-4-carboxylic acid (4.3 mg, 30 μmol) and HATU (11.4 mg, 30 μmol) were combined in DMF (1 mL) and stirred at room temperature for 15 minutes. (2S,4R)-4-amino-5-(5′-chloro-2′-fluorobiphenyl-4-yl)-2-hydroxymethyl-2-methylpentanoic acid (10 mg, 27 μmol) and DIPEA (14 μL, 82 μmol) were added, and the resulting mixture was stirred for 15 minutes at room temperature. The solvent was removed in vacuo and the residue was purified by preparative HPLC to yield the title compound (1.1 mg). MS m/z [M+H]+ calc'd for C23H24ClFN4O5, 491.14. found 491.2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09126956B2 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-f092cf953f254993ac74b0dc02342e92 |
| Source note | uspto-grants-2015_09 |