HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → HCID 73053060, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1) | HCID 9886157 | — |
| Reactant | 2-Hydroxy-1,3-oxazole-5-carboxylic acid | HCID 53981423 | — |
| Reactant | HCID 89964351 | HCID 89964351 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Product | HCID 73053060 | HCID 73053060 | 11.4% |
Reaction Steps
2-Oxo-2,3-dihydrooxazole-5-carboxylic acid (7.1 mg, 55 μmol) and HATU (21 mg, 55 μmol) were combined in DMF (0.3 mL) and stirred at room temperature for 5 minutes. (2S,4R)-4-Amino-5-(5′-chloro-2′-fluorobiphenyl-4-yl)-2-hydroxymethyl-2-methylpentanoic acid (20 mg, 55 μmol) in DMF (0.5 mL) and DIPEA (29 μL, 164 μmol) were added, and the resulting mixture was stirred for 10 minutes at room temperature. The mixture was concentrated under reduced pressure and the residue was dissolved in AcOH purified by preparative HPLC to yield the title compound (3 mg). MS m/z [M+H]+ calc'd for C23H22ClFN2O6, 477.12. found 477.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09126956B2 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-10941a0ca6c7409d8e18ff8071ca324a |
| Source note | uspto-grants-2015_09 |