3-Methoxy-1,2-oxazole-5-carboxylic acid → HCID 89964599, compound

HRID 2275498Notes

Reaction equation

HRID 2275498 reaction equation
[CH3:1][O:2][C:3]1[CH:7]=[C:6]([C:8]([OH:10])=O)[O:5][N:4]=1.[NH2:11][C@H:12]([CH2:23][C:24]1[CH:29]=[CH:28][C:27]([C:30]2[CH:35]=[CH:34][CH:33]=[C:32]([Cl:36])[CH:31]=2)=[CH:26][CH:25]=1)[CH2:13][C@:14]([CH2:19][O:20][CH2:21][CH3:22])([CH3:18])[C:15]([OH:17])=[O:16]>>[Cl:36][C:32]1[CH:31]=[C:30]([C:27]2[CH:26]=[CH:25][C:24]([CH2:23][C@@H:12]([NH:11][C:8]([C:6]3[O:5][N:4]=[C:3]([O:2][CH3:1])[CH:7]=3)=[O:10])[CH2:13][C@:14]([CH2:19][O:20][CH2:21][CH3:22])([CH3:18])[C:15]([OH:17])=[O:16])=[CH:29][CH:28]=2)[CH:35]=[CH:34][CH:33]=1

Participants

3

Reactant 2

HCID 3277173-Methoxy-1,2-oxazole-5-carboxylic acidHCID 89964591HCID 89964591, compound

Product 1

HCID 89964599HCID 89964599, compound

Procedure

3-Methoxyisoxazole-5-carboxylic acid and (2S,4R)-4-amino-5-(3′-chlorobiphenyl-4-yl)-2-ethoxymethyl-2-methylpentanoic acid were reacted as described herein to yield the title compound (2 mg). MS m/z [M+H]+ calc'd for C26H29ClN2O6, 501.17. found 501.2.

Sources & evidence

ORD record
ord-09fe2d539af34cedb2327c1f354e7b30
Source dataset
uspto-grants-2015_09
Patent number
US09126956B2

Reaction notes

Loading…