HCID 89964762, compound → HCID 178494965, compound

HRID 2275499Notes

Reaction equation

HRID 2275499 reaction equation
[OH:1][C:2]1[CH:6]=[C:5]([C:7]([OH:9])=O)[O:4][N:3]=1.C([O:12][C:13](=[O:35])[C@@:14]([CH2:32][O:33][CH3:34])([CH3:31])[CH2:15][C@H:16]([NH2:30])[CH2:17][C:18]1[CH:23]=[CH:22][C:21]([C:24]2[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=2)=[CH:20][CH:19]=1)C>>[C:21]1([C:24]2[CH:25]=[CH:26][CH:27]=[CH:28][CH:29]=2)[CH:20]=[CH:19][C:18]([CH2:17][C@@H:16]([NH:30][C:7]([C:5]2[O:4][N:3]=[C:2]([OH:1])[CH:6]=2)=[O:9])[CH2:15][C@:14]([CH2:32][O:33][CH3:34])([CH3:31])[C:13]([OH:35])=[O:12])=[CH:23][CH:22]=1

Participants

3

Reactant 2

HCID 89964762HCID 89964762, compoundHCID 178524642HCID 178524642, compound

Product 1

HCID 178494965HCID 178494965, compound

Procedure

3-Hydroxy-isoxazole-5-carboxylic acid and (2S,4R)-4-amino-5-biphenyl-4-yl-2-methoxymethyl-2-methylpentanoic acid ethyl ester were reacted as described herein to yield the title compound (2.4 mg). MS m/z [M+H]+ calc'd for C24H26N2O6, 439.18. found 439.2.

Sources & evidence

ORD record
ord-6c57b77e95f9420aa3791b31afe586dd
Source dataset
uspto-grants-2015_09
Patent number
US09126956B2

Reaction notes

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