HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 6-(pyrrole-1-sulfonyl)-2H-pyridazin-3-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 3-Methoxy-6-(pyrrole-1-sulfonyl)-pyridazine | HCID 12071777 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 6-(pyrrole-1-sulfonyl)-2H-pyridazin-3-one | HCID 12071778 | 70.5% |
Reaction Conditions
| Temperature | 100 °C |
|---|
Reaction Steps
A mixture of 3-methoxy-6-(pyrrole-1-sulfonyl)-pyridazine (0.46 mmol, 112 mg), conc. HCl (1 mL) and dioxane (3 mL) was heated at 100° C. for 2 hours. The reaction mixture was cooled and evaporated to dryness. Water (10 mL) was added to the residue and the resulting solid was collected to obtain 6-(pyrrole-1-sulfonyl)-2H-pyridazin-3-one (69%, 73 mg); mp 140° C.-145° C.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06849629B2 |
| Source dataset | uspto-grants-2005_02 |
| ORD ID | ord-d6df9f13005845469ba547fb8e3412a5 |
| Source note | uspto-grants-2005_02 |