tert-Butyl acrylate → HCID 86634101, compound

Participants

Reaction Steps

Heck reaction with tert-butyl acrylate (Step 4) worked well to successfully synthesise 3-(9-amino-acridin-2-yl)-acrylic acid tert-butyl ester (Compound 6). The best condition to reduce the double bond was a catalytic hydrogenation at 3 bars in ethanol. The expected 3-(9-amino-acridin-2-yl)-propionic acid tert-butyl ester (Compound 7) was isolated by column chromatography as the major product. Another isomer and a by-product resulting in the reduction of the aromatic ring were also isolated.

Provenance & Evidence