HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 1-[4-(1H-pyrazol-1-yl)phenyl]cyclopropane-1-carboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | butyl 1-[4-(1H-pyrazol-1-yl)phenyl]cyclopropanecarboxylate | HCID 66661840 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | 1-[4-(1H-pyrazol-1-yl)phenyl]cyclopropane-1-carboxylic acid | HCID 66662411 | — |
Reaction Steps
Trifluoroacetic acid (1.0 mL) was added to butyl 1-[4-(1H-pyrazol-1-yl)phenyl]cyclopropanecarboxylate (60 mg) in methylene chloride (1.0 mL). The mixture was stirred at room temperature overnight, and then concentrated to give a crude product which was directly used in the reaction of next step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09126927B2 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-c4c21c0d6a7e4c3c922f96d422248f8e |
| Source note | uspto-grants-2015_09 |