HuagongsheHuagongshe Chemistry Print Report · For research reference only
Trifluoroacetic acid → 1-(4-Cyclopentylphenyl)cyclopropanecarboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Trifluoroacetic acid | HCID 6422 | — |
| Reactant | Triethylsilane | HCID 12052 | — |
| Reactant | 1-[4-(1-Hydroxycyclopentyl)phenyl]cyclopropanecarboxylic acid | HCID 66662316 | — |
| Product | 1-(4-Cyclopentylphenyl)cyclopropanecarboxylic acid | HCID 66661625 | — |
Reaction Steps
The mixture of 1-[4-(1-hydroxycyclopentyl)phenyl]cyclopropanecarboxylic acid (120 mg, 0.00049 mol), triethylsilane (389 μL, 0.00244 mol) and TFA 0.3 mL was stirred at r.t. overnight. The mixture was concentrated to afford desired product. MS (ESI): 231.1 (M+H+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09126927B2 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-c05c14fa481f4d4ba589c36a4b38bd22 |
| Source note | uspto-grants-2015_09 |