HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → Donepezil Hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Donepezil | HCID 3152 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | Donepezil Hydrochloride | HCID 5741 | — |
Reaction Steps
Donepezil free base (10.0 gm) is dissolved in toluene (50 ml) at 25° C., conc. hydrochloric acid (2.8 ml) is added to the solution and stirred for 6 hours at 25° C. to 30° C. The crystals formed are filtered and dried to give 8.2 gm of donepezil hydrochloride form H2.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07560560B2 |
| Source dataset | uspto-grants-2009_07 |
| ORD ID | ord-59976aee61b74cbba743bbba07a40700 |
| Source note | uspto-grants-2009_07 |