Methanol → HCID 10931849, compound

HRID 227560Notes

Reaction equation

HRID 227560 reaction equation
[CH3:1][C:2]([C:6]([OH:8])=[O:7])([CH2:4][OH:5])[NH2:3].O=S(Cl)Cl.[CH3:13]O>>[CH3:13][O:7][C:6](=[O:8])[C:2]([NH2:3])([CH3:1])[CH2:4][OH:5]

Participants

4

Reactant 3

HCID 887MethanolHCID 24386Thionyl Chloride2×HCID 94309alpha-Methyl-DL-serine

Product 1

HCID 10931849HCID 10931849, compound

Conditions

Temperature
0 °C

Procedure

A stirring solution of α-methyl-DL-Serine (1 g, 8.39 mmol) in MeOH (40 mL) in a flame dried round bottom flask under an inert atmosphere was cooled to 0° C. and SOCl2 (1.84 mL, 25.19 mmol) was slowly added. After addition of the SOCl2 was complete, the reaction mixture was stirred 12 h at rt and then concentrated in vacuo to a white solid that was used directly in the next reaction.

Workup

  1. concentrationconcentrated in vacuo to a white solid that
  2. customwas used directly in the next reaction

Sources & evidence

ORD record
ord-eb51677d170f484bb6b8f0f74eb66b98
Source dataset
uspto-grants-2009_07
Patent number
US07560477B2

Reaction notes

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