HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 1-(4-Aminophenyl)cyclopropanecarboxylic acid
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Tert-butyl1-{4-[(tert-butoxycarbonyl)amino]phenyl}cyclopropanecarboxylate | HCID 66662442 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 1-(4-Aminophenyl)cyclopropanecarboxylic acid | HCID 66662378 | — |
Reaction Steps
4.0 M HCl in dioxane was added to tert-butyl 1-{4-[(tert-butoxycarbonyl)amino]phenyl}cyclopropanecarboxylate (160 mg, 0.00048 mol). After stirring at rt for 2 h, the volatiles were removed in-vacuo and the resulting residue was used in the next step without further purification.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09126927B2 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-972ec1739a2a4a57bc02215ac3de9d28 |
| Source note | uspto-grants-2015_09 |