Water → HCID 66661900, compound

Participants

Reaction Steps

To a solution of methyl (3S,4R)-1-{[1-(4-chlorophenyl)cyclopropyl]carbonyl}-4-phenylpyrrolidine-3-carboxylate (50 mg, 0.0001 mol, example 39) in tetrahydrofuran (2 mL, 0.02 mol) was added lithium hydroxide (9.4 mg, 0.00039 mol) and water (0.5 mL, 0.03 mol) and the solution was stirred at rt for 1 h. The reaction mixture was then acidified (pH˜2) and was extracted with AcOEt. The organic layer was dryed (over MgSO4), and concentrated to afford the product. LCMS: m/z 370.4 (M+H)+

Provenance & Evidence