HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 8-(Methylsulfonyl)-2,8-diazaspiro[4.5]decane hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | 2,8-Diazaspiro[4.5]decane-2-carboxylic acid, 8-(methylsulfonyl)-, 1,1-dimethylethyl ester | HCID 66662714 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 8-(Methylsulfonyl)-2,8-diazaspiro[4.5]decane hydrochloride | HCID 17973614 | — |
Reaction Steps
Hydrogen chloride in 1,4-dioxane (4.0M, 0.50 mL) was added to tert-butyl 8-(methylsulfonyl)-2,8-diazaspiro[4.5]decane-2-carboxylate (21.0 mg, 0.0000659 mol) at rt. The mixture was stirred at rt for 1 h and then the solvent was evaporated, and the residue was dried under high vacuum to afford the desired product. LCMS: m/z 255.5 (M+H)+
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09126927B2 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-da84ea08b0844469bc8effafe31cbff1 |
| Source note | uspto-grants-2015_09 |