HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → 1-{[1-(2,4-Dichlorophenyl)cyclopropyl]carbonyl}pyrrolidin-3-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | 4-Hydroxypyrrolidine | HCID 98210 | — |
| Reactant | Benzotriazol-1-yloxy-tris(dimethylamino)phosphonium hexafluorophosphate | HCID 151348 | — |
| Reactant | 1-(2,4-Dichlorophenyl)cyclopropanecarboxylic acid | HCID 736103 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 1-{[1-(2,4-Dichlorophenyl)cyclopropyl]carbonyl}pyrrolidin-3-ol | HCID 66662728 | — |
Reaction Steps
To a solution of 3-pyrrolidinol (0.861 mL, 0.0106 mol) in N,N-dimethylformamide (5 mL, 0.06 mol) were added 1-(2,4-dichlorophenyl)cyclopropanecarboxylic acid and BOP. After the mixture was stirred for 3 min, DIEA was added. After the reaction mixture was stirred for 3 h, the solution was diluted with AcOEt, washed with sat'd. NaHCO3 aq. (×3), water and brine successively, dried with MgSO4, and concentrated in-vacuo.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09126927B2 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-939909bdd0ef435bb171b8fbdc971285 |
| Source note | uspto-grants-2015_09 |