4-Guanidino-methylphenylalanine → HCID 178512487, compound

HRID 2275689Notes

Reaction equation

HRID 2275689 reaction equation
C([NH:4][CH:5]([C:13]([OH:15])=[O:14])[CH2:6][C:7]1[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1)(=N)N.N[C@@H](CCC[N:35]=[C:36]([NH2:38])[NH2:37])C(N[C@@H](CC1C=CC=CC=1)C(O)=O)=O.N[C@@H](CC1C=CC(CN=C(N)N)=CC=1)C(O)=O.NC(CC1C=CC=CC=1)C(NN)=O.N[C@@H](CC1C=CC=CC=1)C(N[C@@H](CCCN=C(N)N)C(NC1C=CC2C(=CC=CC=2)C=1)=O)=O.CC([C@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](N)CCCNC(N)=N)=O)CCCNC(N)=N)=O)CC1C2C=CC=CC=2NC=1)=O)CS)=O)CC1C=CC=CC=1)=O)CCCNC(N)=N)=O)C(N[C@H](C(N[C@H](C(N[C@H](C(NCC(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(N)=O)CCCNC(N)=N)=O)CS)=O)CCCCN)=O)CCCNC(N)=N)=O)CC1C=CC(O)=CC=1)=O)CS)=O)CC1C=CC=CC=1)=O)=O)CCCNC(N)=N)=O)CC1C=CC(O)=CC=1)=O)CS)=O)C>>[NH:37]([C:10]1[CH:9]=[CH:8][C:7]([CH2:6][C@@H:5]([C:13]([OH:15])=[O:14])[NH2:4])=[CH:12][CH:11]=1)[C:36]([NH2:38])=[NH:35]

Participants

8

Reactant 7

HCID 1509564-Guanidino-methylphenylalanineHCID 150964L-Arginyl-L-phenylalanineHCID 3177202-amino-3-phenylpropanehydrazideHCID 443301HCID 443301, compoundHCID 53324340HCID 53324340, compoundHCID 178512779HCID 178512779, compoundHCID 178512909HCID 178512909, compound

Product 1

HCID 178512487HCID 178512487, compound

Procedure

N-guanyl-dl-phenylalanine; (2S)-2-[[(2S)-2-amino-5-(diaminomethylideneannino)pentanoyl]amino]-3-phenylpropanoic acid, known as arginylphenylalanine; (2S)-2-amino-3-[4-[(diaminomethylideneamino)methyl]phenyl]propanoic acid; 2-amino-3-phenylpropanehydrazide; (2S)-2-[[(2S)-2-amino-3-phenylpropanoyl]amino]-5-(diaminomethylideneamino)-N-naphthalen-2-ylpentanamide; and polyphemusin I or II.

Sources & evidence

ORD record
ord-a059023732ec401ba3263d3872b232f4
Source dataset
uspto-grants-2015_09
Patent number
US09127233B2

Reaction notes

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