Sulfuryl chloride → 1033707-26-4

HRID 2275774Notes

Reaction equation

HRID 2275774 reaction equation
S(Cl)([Cl:4])(=O)=O.[CH:6]1([C:9](=[O:16])[CH2:10][C:11]([O:13][CH2:14][CH3:15])=[O:12])[CH2:8][CH2:7]1>ClCCl>[Cl:4][CH:10]([C:9]([CH:6]1[CH2:8][CH2:7]1)=[O:16])[C:11]([O:13][CH2:14][CH3:15])=[O:12]

Participants

4

Reactant 2

HCID 24648Sulfuryl chlorideHCID 262979Ethyl 3-cyclopropyl-3-oxopropanoate

Product 1

HCID 542445011033707-26-4

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

3.1 ml of sulphuryl chloride (38.2 mmol, 1.05 equivalents) were initially charged in 21 ml of dichloromethane, and 5.68 g of ethyl 3-cyclopropyl-3-oxopropanoate (36.4 mmol) were added dropwise on a water bath. The reaction mixture was stirred at RT for 2 h. The mixture was then washed with water, 5% strength aqueous sodium bicarbonate solution and saturated aqueous sodium chloride solution, dried over magnesium sulphate and concentrated. The crude product (6.8 g) was used without further purification for the next reaction.

Workup

  1. washThe mixture was then washed with water, 5% strength aqueous sodium bicarbonate solution and saturated aqueous sodium chloride solution
  2. dry with materialdried over magnesium sulphate
  3. concentrationconcentrated
  4. customThe crude product (6.8 g) was used without further purification for the next reaction

Sources & evidence

ORD record
ord-91476b64f3a6405788f68526136596eb
Source dataset
uspto-grants-2015_09
Patent number
US09126998B2

Reaction notes

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