Nitric Acid → HCID 86717937, compound

HRID 2275865Notes

Reaction equation

HRID 2275865 reaction equation
Cl.[F:2][C:3]1[CH:8]=[CH:7][N:6]=[CH:5][C:4]=1[OH:9].[N+:10]([O-])([OH:12])=[O:11].[OH-].[Na+]>S(=O)(=O)(O)O>[F:2][C:3]1[CH:8]=[CH:7][N:6]=[C:5]([N+:10]([O-:12])=[O:11])[C:4]=1[OH:9]

Participants

5

Reactant 3

HCID 944Nitric AcidHCID 14798Sodium HydroxideHCID 867179381609166-33-7

Product 1

HCID 86717937HCID 86717937, compound

Reagents, catalysts & solvents 1

HCID 1118Sulfuric AcidSolvent

Procedure

With ice cooling, 500 mg (3.43 mmol) of 4-fluoropyridin-3-ol hydrochloride were dissolved carefully in 3.2 ml of concentrated sulphuric acid, and, at 0° C., 0.21 ml of concentrated nitric acid was added carefully. The reaction was warmed to RT and stirred at RT overnight. The mixture was then added to 10 g of ice, and 6 ml of 45% strength aqueous sodium hydroxide solution were added dropwise with ice cooling. The resulting precipitate was filtered off and then dried under reduced pressure overnight. This gave 191 mg (36% of theory) of the title compound.

Workup

  1. additionwere added dropwise with ice cooling
  2. filtrationThe resulting precipitate was filtered off
  3. customdried under reduced pressure overnight

Sources & evidence

ORD record
ord-8cc86ac62bd24a02ad3b299fe1c03182
Source dataset
uspto-grants-2015_09
Patent number
US09126998B2

Reaction notes

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