HCID 86717937, compound → 2-Amino-4-fluoropyridin-3-ol

HRID 2275866Notes

Reaction equation

HRID 2275866 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([N+:8]([O-])=O)[C:3]=1[OH:11]>C(O)C.[Pd]>[NH2:8][C:4]1[C:3]([OH:11])=[C:2]([F:1])[CH:7]=[CH:6][N:5]=1

Participants

4

Reactant 1

HCID 86717937HCID 86717937, compound

Product 1

HCID 214366942-Amino-4-fluoropyridin-3-ol

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

Under argon, 90 mg (0.57 mmol) of 4-fluoro-2-nitropyridin-3-ol Example 266A were dissolved in 30 ml of ethanol, a spatula tip of 10% palladium on activated carbon was added and the mixture was hydrogenated under atmospheric pressure at RT for 1.5 h. The mixture was then filtered off through silica gel and the filter cake was washed with a lot of ethanol. The solution was concentrated and dried. This gave 56 mg (77% of theory) of the title compound.

Workup

  1. filtrationThe mixture was then filtered off through silica gel
  2. washthe filter cake was washed with a lot of ethanol
  3. concentrationThe solution was concentrated
  4. customdried

Sources & evidence

ORD record
ord-b532794238ae464281b639c71b66e230
Source dataset
uspto-grants-2015_09
Patent number
US09126998B2

Reaction notes

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