化工社化工社 化学情報印刷レポート · 研究参考用
2-Aminothiazole → N-[2-(3,4-Dimethoxyphenoxy)phenyl]-N'-(thiazol-2-yl)urea
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Aminothiazole | HCID 2155 | — |
| 反応物 | 3,4-Dimethoxyphenol | HCID 16251 | — |
| 反応物 | 1-Fluoro-2-nitrobenzene | HCID 73895 | — |
| 反応物 | 2-(3,4-Dimethoxyphenoxy)benzenamine | HCID 49766595 | — |
| 生成物 | 1,2-Dimethoxy-4-(2-nitrophenoxy)benzene | HCID 11369382 | 68% |
| 生成物 | N-[2-(3,4-Dimethoxyphenoxy)phenyl]-N'-(thiazol-2-yl)urea | HCID 59732827 | 69% |
反応手順
2-(3,4-Dimethoxyphenoxy)-1-nitrobenzene (0.93 g, 68%) was prepared from 3,4-dimethoxyphenol (0.85 g, 5.5 mmol) and 1-fluoro-2-nitrobenzene (0.71 g, 5.0 mmol) following the general procedure A. This was reduced to 2-(3,4-dimethoxyphenoxy)aniline (0.51 g, 62%) following general procedure B. N-[2-(3,4-Dimethoxyphenoxy)phenyl]-N′-(thiazol-2-yl)urea (128 mg, 69%) was prepared from 2-(3,4-dimethoxyphenoxy)aniline (123 mg, 0.5 mmol) and 2-aminothiazole (60 mg, 0.6 mmol) following the general procedure D.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | USRE045670E1 |
| 出典データセット | uspto-grants-2015_09 |
| ORD ID | ord-61568dcf58c84d30948c95186b09be14 |
| 出典メモ | uspto-grants-2015_09 |