Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Bromine | HCID 24408 | — |
| Reactant | 5-(4-Nitrophenyl)thieno[2,3-d]pyrimidin-4-amine | HCID 59794248 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Solvent | Dimethylformamide | HCID 6228 | — |
| Solvent | Sodium Bicarbonate | HCID 516892 | — |
| Product | HCID 69054306 | HCID 69054306 | — |
Reaction Steps
A suspension of Example 58C (50 mg, 0.18 mmol) in acetic acid (1 mL) and DMF (3 mL) was heated with a heat gun to obtain a clear solution, cooled to 0° C., and treated with bromine (0.02 mL). The reaction mixture was stirred at 0° C. for 1 hour, diluted with saturated NaHCO3, and filtered. The filter cake was dried to provide 56 mg of the desired product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US07560552B2 |
|---|
| Source dataset | uspto-grants-2009_07 |
|---|
| ORD ID | ord-2ed0f528beef43c986ccabe2b2a9d6ea |
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| Source note | uspto-grants-2009_07 |
|---|
