HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Aminothiazole → 2-(2-Isopropoxyphenoxy)-1-nitrobenzene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Aminothiazole | HCID 2155 | — |
| Reactant | 2-Isopropoxyphenol | HCID 20949 | — |
| Reactant | 1-Fluoro-2-nitrobenzene | HCID 73895 | — |
| Reactant | 2-(2-Methoxyphenoxy)aniline | HCID 254144 | — |
| Reactant | 2-(2-Isopropoxyphenoxy)aniline | HCID 66998985 | — |
| Product | N-[2-(2-Isopropoxyphenoxy)phenyl]-N'-(thiazol-2-yl)urea | HCID 59732946 | 65% |
| Product | 2-(2-Isopropoxyphenoxy)-1-nitrobenzene | HCID 66998920 | 69% |
Reaction Steps
2-(2-Isopropoxyphenoxy)-1-nitrobenzene (0.90 g, 69%) was prepared from 2-isopropoxyphenol (0.84 g, 5.5 mmol) and 1-fluoro-2-nitrobenzene (0.71 g, 5.0 mmol) following the general procedure A. This was reduced to 2-(2-methoxyphenoxy)aniline (0.65 g, 81%) following general procedure B. N-[2-(2-Isopropoxyphenoxy)phenyl]-N′-(thiazol-2-yl)urea (120 mg, 65%) was prepared from 2-(2-isopropoxyphenoxy)aniline (122 mg, 0.5 mmol) and 2-aminothiazole (60 mg, 0.6 mmol) following the general procedure D.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | USRE045670E1 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-922dc901b9984c1192e1a7a1d2401579 |
| Source note | uspto-grants-2015_09 |