HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Aminothiazole → N-[5-Fluoro-2-(2-fluoro-6-methoxyphenoxy)phenyl]-N'-(thiazol-2-yl)urea
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Aminothiazole | HCID 2155 | — |
| Reactant | 2,5-Difluoronitrobenzene | HCID 67767 | — |
| Reactant | 2-Fluoro-6-methoxyphenol | HCID 2737367 | — |
| Reactant | 5-Fluoro-2-(2-fluoro-6-methoxyphenoxy)aniline | HCID 66998239 | — |
| Product | N-[5-Fluoro-2-(2-fluoro-6-methoxyphenoxy)phenyl]-N'-(thiazol-2-yl)urea | HCID 59732911 | 69% |
| Product | 5-Fluoro-2-(2-fluoro-6-methoxyphenoxy)-1-nitrobenzene | HCID 66998975 | 65% |
Reaction Steps
5-Fluoro-2-(2-fluoro-6-methoxyphenoxy)-1-nitrobenzene (0.91 g, 65%) was prepared from 2-fluoro-6-methoxyphenol (0.78 g, 5.5 mmol) and 2,5-difluoro-1-nitrobenzene (0.80 g, 5.0 mmol) following the general procedure A. This was reduced to 5-fluoro-2-(2-fluoro-6-methoxyphenoxy)aniline (0.66 g, 81%) following general procedure C. N-[5-Fluoro-2-(2-fluoro-6-methoxyphenoxy)phenyl]-N′-(thiazol-2-yl)urea (130 g, 69%) was prepared from 5-fluoro-2-(2-fluoro-6-methoxyphenoxy)aniline (126 mg, 0.5 mmol) and 2-aminothiazole (60 mg, 0.6 mmol) following the general procedure D.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | USRE045670E1 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-b0fdd0272dc9480494b461cc41aadd6c |
| Source note | uspto-grants-2015_09 |