化工社化工社 化学情報印刷レポート · 研究参考用
2-Aminothiazole → 2-(2,3-Dimethoxyphenoxy)-6-fluoro-nitrobenzene
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Aminothiazole | HCID 2155 | — |
| 反応物 | 2,3-Dimethoxyphenol | HCID 78828 | — |
| 反応物 | 1,3-Difluoro-2-nitrobenzene | HCID 87922 | — |
| 反応物 | 2-(2,3-Dimethoxyphenoxy)-6-fluoroaniline | HCID 66998905 | — |
| 触媒 | N-[2-(2,3-Dimethoxyphenoxy)-6-fluorophenyl]-N'-(thiazol-2-yl)urea | HCID 59732837 | — |
| 生成物 | 2-(2,3-Dimethoxyphenoxy)-6-fluoro-nitrobenzene | HCID 66999009 | 72% |
反応手順
2-(2,3-Dimethoxyphenoxy)-6-fluoro-nitrobenzene (1.05 g, 72%) was prepared from 2,3-dimethoxyphenol (0.85 g, 5.5 mmol) and 2,6-difluoronitrobenzene (0.80 g, 5.0 mmol) following the general procedure A. This compound was reduced to 2-(2,3-dimethoxyphenoxy)-6-fluoroaniline (0.66 g, 70%) following the general procedure C N-[2-(2,3-Dimethoxyphenoxy)-6-fluorophenyl]-N′-(thiazol-2-yl)urea (136 mg, 70%) was prepared from 2-(2,3-dimethoxyphenoxy)-6-fluoroaniline (131 mg, 0.5 mmol) and 2-aminothiazole (60 mg, 0.6 mmol) following the general procedure D.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | USRE045670E1 |
| 出典データセット | uspto-grants-2015_09 |
| ORD ID | ord-f33d04c93787465595b6a391a688ba25 |
| 出典メモ | uspto-grants-2015_09 |