2-Aminothiazole → N-[2-(2,3-dimethoxyphenoxy)-4-fluorophenyl]-N'-(thiazol-2-yl)urea

Participants

Role	Name	HCID	Charge
Reactant	2-Aminothiazole	HCID 2155	—
Reactant	2,4-Difluoronitrobenzene	HCID 67967	—
Reactant	2,3-Dimethoxyphenol	HCID 78828	—
Reactant	2-(2,3-Dimethoxyphenoxy)-4-fluoroaniline	HCID 66999039	—
Product	N-[2-(2,3-dimethoxyphenoxy)-4-fluorophenyl]-N'-(thiazol-2-yl)urea	HCID 59732915	60%
Product	2-(2,3-Dimethoxyphenoxy)-4-fluoro-1-nitrobenzene	HCID 66999043	60%

Reaction Steps

2-(2,3-Dimethoxyphenoxy)-4-fluoro-1-nitrobenzene (0.88 g, 60%) was prepared from 2,3-dimethoxyphenol (0.85 g, 5.5 mmol) and 2,4-difluoro-1-nitrobenzene (0.8 g, 5.0 mmol) following the general procedure F. This compound was reduced to 2-(2,3-dimethoxyphenoxy)-4-fluoroaniline (0.52 g, 66%) following the general procedure C. N-[2-(2,3-dimethoxyphenoxy)-4-fluorophenyl]-N′-(thiazol-2-yl)urea (116 mg, 60%) was prepared from 2-(2,3-dimethoxyphenoxy)-4-fluoroaniline (132 mg, 0.5 mmol) and 2-aminothiazole (60 mg, 0.6 mmol) following the general procedure D.

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	USRE045670E1
Source dataset	uspto-grants-2015_09
ORD ID	ord-eb6d070dab534ea2a0f3d13fd3e48bd0
Source note	uspto-grants-2015_09