HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Aminothiazole → [3-Cyclopentanecarbonyl-4-(3-thiazol-2-yl-ureido)phenyl]acetic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Aminothiazole | HCID 2155 | — |
| Reactant | Cyclopentanecarbonitrile | HCID 77935 | — |
| Reactant | p-Aminophenylacetic acid ethyl ester | HCID 225219 | — |
| Reactant | (4-Amino-3-cyclopentanecarbonylphenyl)acetic acid ethyl ester | HCID 66998892 | — |
| Product | [3-Cyclopentanecarbonyl-4-(3-thiazol-2-yl-ureido)phenyl]acetic acid ethyl ester | HCID 59732863 | — |
| Product | (4-Amino-3-cyclopentanecarbonylphenyl)acetic acid ethyl ester | HCID 66998892 | — |
Reaction Steps
(4-Amino-3-cyclopentanecarbonylphenyl)acetic acid ethyl ester (2.7 g) is prepared from (4-aminophenyl)acetic acid ethyl ester (18.0 g, 0.1 mol) and cyclopentanecarbonitrile (9.5 g, 0.1 mol) following the general procedure I. [3-Cyclopentanecarbonyl-4-(3-thiazol-2-yl-ureido)phenyl]acetic acid ethyl ester (140 mg) is prepared from (4-amino-3-cyclopentanecarbonylphenyl)acetic acid ethyl ester (138 mg, 0.5 mmol) and 2-aminothiazole (0.060 g, 0.6 mmol) following the general procedure D.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | USRE045670E1 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-3f9ce46ff37949e08b89265d663d2c79 |
| Source note | uspto-grants-2015_09 |