3-Amino-3-(4-nitrophenyl)-2-cyanoacrylonitrile → (2z)-3-Amino-2-cyano-3-(4-nitrophenyl)prop-2-enethioamide

Participants

Reaction Steps

A suspension of Example 96C (2.1 g, 9.8 mmol) and 90% diethyl dithiophosphate (1.8 mL, 10.8 mmol) in ethanol (15 mL) and water (15 mL) was heated to reflux for 24 hours, cooled to room temperature, poured into ice water (300 mL), and filtered. The filter cake was dried to provide 2.3 g (95% yield) of the desired product. MS(ESI(−)) m/e 247 (M−H)−.

Provenance & Evidence