HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrogen Peroxide → 5-Amino-3-(4-nitrophenyl)isothiazole-4-carbonitrile
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrogen Peroxide | HCID 784 | — |
| Reactant | (2z)-3-Amino-2-cyano-3-(4-nitrophenyl)prop-2-enethioamide | HCID 59099563 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 5-Amino-3-(4-nitrophenyl)isothiazole-4-carbonitrile | HCID 69055185 | 96.5% |
Reaction Steps
A suspension of Example 96D (23 g, 9.26 mmol) in ethanol (100 mL) was treated with 31% H2O2 (2 mL, 1.85 mmol), stirred at room temperature overnight, poured into ice water, and filtered. The filter cake was washed with water and dried to provide 2.2 g (96% yield) of the desired product. MS(ESI(−)) m/e 245 (M−H)−.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07560552B2 |
| Source dataset | uspto-grants-2009_07 |
| ORD ID | ord-28102a87a99b45adacc2af2fa4632385 |
| Source note | uspto-grants-2009_07 |