HuagongsheHuagongshe Chemistry Print Report · For research reference only
Formamide → 3-(4-Nitrophenyl)isothiazolo[5,4-d]pyrimidin-4-amine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Formamide | HCID 713 | — |
| Reactant | Water | HCID 962 | — |
| Reactant | 5-Amino-3-(4-nitrophenyl)isothiazole-4-carbonitrile | HCID 69055185 | — |
| Product | 3-(4-Nitrophenyl)isothiazolo[5,4-d]pyrimidin-4-amine | HCID 44414742 | 84% |
Reaction Steps
A mixture of Example 96E (200 mg) in formamide (5 mL) in a capped vial was heated to 210° C. in a Smith microwave oven at 300W for 25 minutes, poured into water, and filtered. The filter cake was dried to provide 2.02 g (84% yield) of the desired product. MS(ESI(+)) m/e 274 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07560552B2 |
| Source dataset | uspto-grants-2009_07 |
| ORD ID | ord-cb325f8a8a724487b8bc4591735c1aec |
| Source note | uspto-grants-2009_07 |