HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Aminothiazole → 3-(3-Methyl-butoxy)-4-nitrotoluene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Aminothiazole | HCID 2155 | — |
| Reactant | Benzene, 2-fluoro-4-methyl-1-nitro- | HCID 67966 | — |
| Reactant | 4-Methyl-2-(3-methylbutoxy)aniline | HCID 26189526 | — |
| Solvent | Isoamyl Alcohol | HCID 31260 | — |
| Product | 1-(Thiazol-2-yl)urea | HCID 16781708 | 76% |
| Product | 3-(3-Methyl-butoxy)-4-nitrotoluene | HCID 66999028 | 80% |
Reaction Steps
3-(3-Methyl-butoxy)-4-nitrotoluene (0.89 g, 80%) was prepared from 3-methylbutanol and 3-fluoro-4-nitrotoluene (0.77 g, 5.0 mmol) following the general procedure G. This was reduced to 4-methyl-2-(3-methylbutoxy)aniline (0.55 g, 72%) following general procedure C. 1-[4-Methyl-2-3-methyl-butoxy)-phenyl]-3-thiazol-2-yl-urea (240 mg, 76%) was prepared from 4-methyl-2-(3-methyl-butoxy)aniline (193 mg, 1.0 mmol) and 2-aminothiazole (100 mg, 1.0 mmol) following the general procedure D.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | USRE045670E1 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-94bd547e127b476985177745ac91f6b2 |
| Source note | uspto-grants-2015_09 |