HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Aminothiazole → 4-(2-Methylpropoxy)-3-nitrobenzaldehyde
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Aminothiazole | HCID 2155 | — |
| Reactant | Isobutanol | HCID 6560 | — |
| Reactant | 4-Fluoro-3-nitrobenzaldehyde | HCID 598129 | — |
| Reactant | 5-Formyl-2-(2-methylpropoxy)aniline | HCID 82057088 | — |
| Product | 4-(2-Methylpropoxy)-3-nitrobenzaldehyde | HCID 28829481 | 75% |
| Product | 1-(5-Formyl-2-isobutoxy-phenyl)-3-thiazol-2-yl-urea | HCID 59732785 | 65% |
Reaction Steps
4-(2-Methylpropoxy)-3-nitrobenzaldehyde (0.83 g, 75%) was prepared from 2-methyl-propanol (0.46 ml, 5.0 mmol) and 4-fluoro-3-nitrobenzaldehyde (0.77 g, 5.0 mmol) following the general procedure G. This was reduced to 5-formyl-2-(2-methylpropoxy)-aniline (0.49 g, 68%) following general procedure B. 1-(5-Formyl-2-isobutoxy-phenyl)-3-thiazol-2-yl-urea (208 mg, 65%) was prepared from 5-formyl-2-(2-methylpropoxy)aniline (193 mg, 1.0 mmol) and 2-aminothiazole (100 mg, 1.0 mmol) following the general procedure D.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | USRE045670E1 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-2115c5c94a374d91a6e762878d7a2bf6 |
| Source note | uspto-grants-2015_09 |