Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
2-Aminothiazole → 2-Nitrotoluene
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | 2-Aminothiazole | HCID 2155 | — |
| 반응물 | Benzene, 2-fluoro-4-methyl-1-nitro- | HCID 67966 | — |
| 반응물 | 2-Fluoro-6-methoxyphenol | HCID 2737367 | — |
| 반응물 | 4-Fluoro-2-(2-fluoro-6-methoxyphenoxy)aniline | HCID 66998878 | — |
| 반응물 | 2-(2-Fluoro-6-methoxy-phenoxy)-4-methyl-aniline | HCID 66999002 | — |
| 생성물 | 2-Nitrotoluene | HCID 6944 | 65% |
| 생성물 | 1-[2-(2-Fluoro-6-methoxy-phenoxy)-4-methyl-phenyl]-3-thiazol-2-yl-urea | HCID 59732805 | 65% |
반응 단계
3-2-fluoro-6-methoxyphenoxy)-nitrotoluene (0.9 g, 65%) was prepared from 2-fluoro-6-methoxyphenol (0.78 g, 5.5 mmol) and 3-fluoro-4-nitrotoluene (0.77 g, 5.0 mmol) following the general procedure A. This compound was reduced to 4-fluoro-2-(2-fluoro-6-methoxyphenoxy)aniline (0.58 g, 72%) following the general procedure C. 1-[2-(2-Fluoro-6-methoxy-phenoxy)-4-methyl-phenyl]-3-thiazol-2-yl-urea (122 mg, 65%) was prepared from 2-(2-fluoro-6-methoxy-phenoxy)-4-methyl-aniline (124 mg, 0.5 mmol) and 2-aminothiazole (60 mg, 0.6 mmol) following the general procedure D.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | USRE045670E1 |
| 출처 데이터셋 | uspto-grants-2015_09 |
| ORD ID | ord-3eacb9ae83494e7c96dafcc95faff228 |
| 출처 메모 | uspto-grants-2015_09 |