HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl chloroacetate → HCID 86340127, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl chloroacetate | HCID 7751 | — |
| Reactant | Lithium Carbonate | HCID 11125 | — |
| Reactant | 3,5-Dibromo-4-methylaniline | HCID 7015779 | — |
| Solvent | N-methyl-2-pyrrolidone | HCID 13387 | — |
| Product | HCID 86340127 | HCID 86340127 | 33% |
Reaction Steps
The DNA ligase inhibitor L67 (10) was synthesized by incubation of ethyl chloroacetate with 3,5-dibromo-4-methylaniline in the presence of lithium carbonate in N-methyl-2-pyrrolidinone as the solvent at 100° C. for 16 hours to produce N-(3,5-dibromo-4-methylphenyl)glycine ethyl ester in 33% yield after recrystallization from ethanol.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US09132120B1 |
| Source dataset | uspto-grants-2015_09 |
| ORD ID | ord-116275f650ef4720818cc70fde8f0a2a |
| Source note | uspto-grants-2015_09 |