Propanal → HCID 49819035, compound

Participants

Reaction Steps

5-amino-2-(4-methoxybenzylsulfanyl)-6-methylamino-4-morpholinopyrimidine (693 mg, 1.91 mmol) was dissolved in methanol (20 ml), propionaldehyde (2.76 ml, 38.3 mmol) was added and stirred at room temperature for 3 hours. The solvent was distilled away under reduced pressure, water was added and extracted twice with ethyl acetate. After combining the organic layers and washing with a saturated saline solution, it was dried with MgSO4 and the solvent was distilled away under reduced pressure. Separation and purification were performed by silica gel column chromatography (ethyl acetate:hexane=1:1) to obtain 610 mg (80% yield) of 8-ethyl-2-(4-methoxybenzylsulfanyl)-9-methyl-6-morpholino-9H-purine.

Provenance & Evidence