HCID 66597624, compound → HCID 49819036, compound

Participants

Reaction Steps

8-ethyl-9-methyl-6-morpholino-2-(3-nitro-4-methoxybenzylsulfanyl)-9H-purine (4.10 g, 9.23 mmol) was dissolved in dichloromethane (50 ml) and methanol (50 ml), 1.0 g of Pd/C was added and catalytic hydrogenation was performed under normal pressure for 18 hours. Celite was used to filter off Pd/C, and the filtrate was distilled away under reduced pressure. Ether was added to the residue and the precipitated crystals were collected by filtration to obtain 2.74 g (72% yield) of 2-(3-amino-4-methoxybenzylsulfanyl)-8-ethyl-9-methyl-6-morpholino-9H-purine.

Provenance & Evidence