Water → HCID 49819589, compound

Participants

Reaction Steps

2-(3-amino-4-methoxybenzylsulfanyl)-8-ethyl-9-methyl-6-morpholino-9H-purine (100 mg, 0.24 mmol) was dissolved in tetrahydrofuran (10 ml), triethylamine (49 mg, 0.48 mmol) and acetyl chloride (38 mg, 0.48 mmol) were added and stirred at room temperature overnight. After adding water to the reaction solution and extracting twice with ethyl acetate, the organic layers were washed with a saturated saline solution and dried with MgSO4. After distilling away the solvent under reduced pressure, purification was performed by silica gel column chromatography (ethyl acetate:hexane=1:1) to obtain 77 mg (70% yield) of Compound 27.

Provenance & Evidence