HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2276296Generated: October 29, 2026
Dimethylformamide → HCID 178491707, compound
https://huagongshe.com/reaction/2276296
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 2-Thioxanthine | HCID 1268185 | — |
| Reactant | 4-(Bromomethyl)-1-methoxy-2-nitrobenzene | HCID 11579648 | — |
| Solvent | Water | HCID 962 | — |
| Product | HCID 178491707 | HCID 178491707 | 95.7% |
Reaction Steps
A DMF (100 ml) solution of 2-thioxanthine (7.75 g, 46 mmol), triethylamine (8.0 ml, 60 mmol), 4-methoxy-3-nitrobenzyl bromide (12.48 g, 51 mmol) was heated and stirred at 100° C. for 3 hours. Water was added to the reaction solution, the precipitated crystals were collected by filtration and washed sequentially with water and ether to obtain 14.67 g (95% yield) of 6-hydroxy-2-(4-methoxy-3-nitrobenzylsulfanyl)-9H-purine.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US09132130B2 |
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| Source dataset | uspto-grants-2015_09 |
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| ORD ID | ord-d4a69178f3eb41cdba233ec78437c733 |
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| Source note | uspto-grants-2015_09 |
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