Water → HCID 86663940, compound

Participants

Reaction Steps

6-chloro-2-(4-methoxy-3-nitrobenzylsulfanyl)-9H-purine (2.00 g, 6.3 mmol) was dissolved in N,N-dimethylformamide (20 ml), under ice cooling, 60% sodium hydride (0.30 g, 7.6 mmol) was added and stirred for 5 minutes, then methyl iodide (1.08 g, 0.76 mmol) was added and stirred overnight. Water was added to the reaction solution, the precipitated crystals were collected by filtration and washed sequentially with water and ether to obtain 2.06 g (89% yield) of 6-chloro-2-(4-methoxy-3-nitrobenzylsulfanyl)-9-methyl-9H-purine.

Provenance & Evidence