Triethylamine → HCID 66596962, compound

Participants

Reaction Steps

6-chloro-2-(4-methoxy-3-nitrobenzylsulfanyl)-9-methyl-9H-purine (850 mg, 2.32 mmol) was dissolved in tetrahydrofuran (100 ml), triethylamine (1.57 g, 15.51 mmol) and 2-ethoxymorpholine hydrochloride (520 mg, 3.10 mmol) were added and heated to reflux for 7 hours. After distilling away the solvent under reduced pressure, water was added to the residue and extracted twice with ethyl acetate, then the organic layers were washed with a saturated saline solution and dried with MgSO4. After distilling away the solvent under reduced pressure, purification was performed by silica gel column chromatography (ethyl acetate:hexane=1:3) to obtain 738 mg (69% yield) of 6-(2-ethoxymorpholino)-2-(4-methoxy-3-nitrobenzylsulfanyl)-9-methyl-9H-purine.

Provenance & Evidence