1H-indazol-3-amine → HCID 178499486, compound

Participants

Reaction Steps

A mixture of a dimethyl acetylsuccinate (1.55 g; 8.27 mmol) and 1H-indazol-3-amine (1 g; 7.5 mmol) in toluene (7.5 mL) was heated to reflux under a Dean Stark system for 48 h. The precipitate was filtered-off, washed with toluene and diethylether to afford 1.34 g (67%) of methyl 2-(4-hydroxy-2-methylpyrimido[1,2-b]indazol-3-yl)acetate, which was used for the next step without any further purification. ESI/APCI(+): 272 (M+H).

Provenance & Evidence