反应详情

温度

70 °C

A solution of Example 338B (0.37 g, 1.29 mmol) in methanol (3 mL) was treated with LiOCH3 (1.4 mL, 1M in methanol), and heated to 70° C. for 4 hours. The reaction was cooled to room temperature resulting in a brown precipitate which was collected by filtration. The filter cake was washed with cold methanol and dried to provide 0.175 g of the desired product. MS (ESI(+)) m/e 288 (M+H)+.

1. temperatureThe reaction was cooled to room temperature
2. customresulting in a brown precipitate which
3. filtrationwas collected by filtration
4. washThe filter cake was washed with cold methanol
5. customdried