Diazepam → 122955-42-4
Reaction equation
[CH3:1][N:2]1C(=O)CN=C(C2C=CC=CC=2)[C:8]2[CH:7]=[C:6](Cl)[CH:5]=[CH:4][C:3]1=2.C1C=CC(C(N[CH2:35][CH2:36][NH:37][CH:38]([C:45]2[CH:50]=[CH:49]C=CC=2)C2C=CC=CC=2)C2C=CC=CC=2)=CC=1.Cl.Cl.N[C@@H:54](C(O)=O)CCSC.C1N(COC(CO)CO)C2N=C(N)N=C(O)C=2N=1.C1C(/C=[CH:87]/[C:88]2C=[C:92]([OH:94])[CH:91]=[C:90](O)[CH:89]=2)=CC=C(O)C=1.[CH2:97]1[C@H:102](N)[C@@H:101](O[C@H]2O[C@H](CN)[C@@H](O)[C@H](O)[C@H]2N)[C@H:100](O[C@@H]2O[C@H](CO)[C@@H](O[C@H]3O[C@@H](CN)[C@@H](O)[C@H](O)[C@H]3N)[C@H]2O)[C@@H:99](O)[C@@H:98]1N>>[CH:97]1[CH:98]=[C:99]2[C:92]([C:91]3[C:1]([C:2]([CH2:3][C:4]4[CH:5]=[CH:6][N:7]=[CH:8][CH:54]=4)([CH2:49][C:50]4[CH:35]=[CH:36][N:37]=[CH:38][CH:45]=4)[C:100]2=[CH:101][CH:102]=1)=[CH:87][CH:88]=[CH:89][CH:90]=3)=[O:94]Participants
7
Procedure
Mucoadhesive thermoreversible gel formulations comprising diazepam, AMN082, D-methionine, Ganciclovir, SRT-501, neomycin, the KCNQ modulator XE-991 are prepared using a procedure similar to the procedure in Example 11. In further examples, mucoadhesive thermoreversible gel formulations comprising micronized diazepam, AMN082, D-methionine, Ganciclovir, SRT-501, neomycin, the KCNQ modulator XE-991 are prepared using a procedure similar to the procedure in Example 11.
Workup
- customthe KCNQ modulator XE-991 are prepared
Sources & evidence
- ORD record
- ord-184deb1a2ec04deb97439e28d300c577
- Source dataset
- uspto-grants-2015_09
- Patent number
- US09132087B2
Reaction notes
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