Chlorosuccinimide → N-Hydroxy-2-(trifluoromethyl)benzene-1-carboximidoyl chloride

HRID 2276397ノート

反応式

HRID 2276397 の反応式
[F:1][C:2]([F:13])([F:12])[C:3]1[CH:11]=[CH:10][CH:9]=[CH:8][C:4]=1[CH:5]=[N:6][OH:7].[Cl:14]N1C(=O)CCC1=O>>[OH:7][N:6]=[C:5]([Cl:14])[C:4]1[CH:8]=[CH:9][CH:10]=[CH:11][C:3]=1[C:2]([F:12])([F:13])[F:1]

参加物

3

反応物 2

HCID 31398ChlorosuccinimideHCID 16173382-(Trifluoromethyl)benzenecarbaldehyde oxime

生成物 1

HCID 53395456N-Hydroxy-2-(trifluoromethyl)benzene-1-carboximidoyl chloride収率 93%

実験手順

2-(trifluoromethyl)benzaldehydeoxime (30.0 g, 158.60 mmol) was dissolved in dimethylformimide (300 mL), and added with N-chlorosuccinimide (23.31 g, 174.46 mmol), followed by stirring for 15 hours. After the reaction was completed, the resultant solution was vacuum evaporated, added with ethylacetate (1,500 mL), washed with saturated sodium chloride aqueous solution (1,000 mL) and purified water (1,000 mL), respectively, dried with anhydrous sodium sulfate, and vacuum-evaporated to provide a pale yellow solid required compound (32.81 g, 146.70 mmol, 93%).

後処理

  1. customevaporated
  2. additionadded with ethylacetate (1,500 mL)
  3. washwashed with saturated sodium chloride aqueous solution (1,000 mL)
  4. custompurified water (1,000 mL)
  5. dry with materialrespectively, dried with anhydrous sodium sulfate
  6. customvacuum-evaporated

出典と根拠

ORDレコード
ord-b510498aac614bb1911441cdc1175ce2
出典データセット
uspto-grants-2015_09
特許番号
US09132126B2

反応ノート

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