反应详情

2-(trifluoromethyl)benzaldehydeoxime (30.0 g, 158.60 mmol) was dissolved in dimethylformimide (300 mL), and added with N-chlorosuccinimide (23.31 g, 174.46 mmol), followed by stirring for 15 hours. After the reaction was completed, the resultant solution was vacuum evaporated, added with ethylacetate (1,500 mL), washed with saturated sodium chloride aqueous solution (1,000 mL) and purified water (1,000 mL), respectively, dried with anhydrous sodium sulfate, and vacuum-evaporated to provide a pale yellow solid required compound (32.81 g, 146.70 mmol, 93%).

1. customevaporated
2. additionadded with ethylacetate (1,500 mL)
3. washwashed with saturated sodium chloride aqueous solution (1,000 mL)
4. custompurified water (1,000 mL)
5. dry with materialrespectively, dried with anhydrous sodium sulfate
6. customvacuum-evaporated