Methyl acetoacetate → HCID 70980969, compound

HRID 2276404Notes

Reaction equation

HRID 2276404 reaction equation
[OH:1][N:2]=[C:3](Cl)[C:4]1[CH:9]=[CH:8][C:7]([O:10][C:11]([F:14])([F:13])[F:12])=[CH:6][CH:5]=1.[CH3:16][O:17][C:18](=[O:23])[CH2:19][C:20]([CH3:22])=O.C[O-].[Na+]>CO>[CH3:16][O:17][C:18]([C:19]1[C:3]([C:4]2[CH:9]=[CH:8][C:7]([O:10][C:11]([F:14])([F:13])[F:12])=[CH:6][CH:5]=2)=[N:2][O:1][C:20]=1[CH3:22])=[O:23]

Participants

5

Reactant 3

HCID 7757Methyl acetoacetateHCID 10942334Sodium MethoxideHCID 86210273HCID 86210273, compound

Product 1

HCID 70980969HCID 70980969, compoundYield 67%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

In a similar manner as described in Preparation Example 17, by using methanol (160 mL), N-hydroxy-4-(trifluoromethoxy)benzimidoylchloride (8.00 g, 33.39 mmol), methylacetoacetate (7.76 g, 66.78 mmol) and sodium methoxide (5.41 g, 100.17 mmol), a white solid required compound (6.74 g, 22.36 mmol, 67%) was obtained.

Workup

  1. customIn a similar manner as described in Preparation Example 17

Sources & evidence

ORD record
ord-8f132c0d22f04d97aab86278e6e4cd9c
Source dataset
uspto-grants-2015_09
Patent number
US09132126B2

Reaction notes

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