Methyl acetoacetate → HCID 70982049, compound

HRID 2276406Notes

Reaction equation

HRID 2276406 reaction equation
[OH:1][N:2]=[C:3](Cl)[C:4]1[CH:9]=[CH:8][CH:7]=[C:6]([O:10][C:11]([F:14])([F:13])[F:12])[CH:5]=1.[CH3:16][O:17][C:18](=[O:23])[CH2:19][C:20]([CH3:22])=O.C[O-].[Na+]>CO>[CH3:16][O:17][C:18]([C:19]1[C:3]([C:4]2[CH:9]=[CH:8][CH:7]=[C:6]([O:10][C:11]([F:14])([F:13])[F:12])[CH:5]=2)=[N:2][O:1][C:20]=1[CH3:22])=[O:23]

Participants

5

Reactant 3

HCID 7757Methyl acetoacetateHCID 10942334Sodium MethoxideHCID 86709606HCID 86709606, compound

Product 1

HCID 70982049HCID 70982049, compoundYield 68%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

In a similar manner as described in Preparation Example 17, by using methanol (160 mL), N-hydroxy-3-(trifluoromethoxy)benzimidoylchloride (8.00 g, 33.39 mmol), methylacetoacetate (7.76 g, 66.78 mmol) and sodium methoxide (5.41 g, 100.17 mmol), a white solid required compound (6.82 g, 22.64 mmol, 68%) was obtained.

Workup

  1. customIn a similar manner as described in Preparation Example 17

Sources & evidence

ORD record
ord-65ada34a163940c495f2b96c294315fa
Source dataset
uspto-grants-2015_09
Patent number
US09132126B2

Reaction notes

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