Sodium Hydroxide → 3-(3-Fluorophenyl)-5-methyl-1,2-oxazole-4-carboxylic acid

HRID 2276409Notes

Reaction equation

HRID 2276409 reaction equation
C[O:2][C:3]([C:5]1[C:6]([C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([F:17])[CH:12]=2)=[N:7][O:8][C:9]=1[CH3:10])=[O:4].[OH-].[Na+]>CO>[F:17][C:13]1[CH:12]=[C:11]([C:6]2[C:5]([C:3]([OH:4])=[O:2])=[C:9]([CH3:10])[O:8][N:7]=2)[CH:16]=[CH:15][CH:14]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 70981314HCID 70981314, compound

Product 1

HCID 234478823-(3-Fluorophenyl)-5-methyl-1,2-oxazole-4-carboxylic acidYield 98%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

In a similar manner as described in Preparation Example 25, by using methanol (60 mL), methyl-3-(3-fluorophenyl)-5-methylisoxazol-4-carboxylate (6.0 g, 25.51 mmol) and 3% sodium hydroxide aqueous solution (60 mL), a white solid required compound (5.51 g, 24.92 mmol, 98%) was obtained.

Workup

  1. customIn a similar manner as described in Preparation Example 25

Sources & evidence

ORD record
ord-d09ca920cff74cb98e6432eec3254b25
Source dataset
uspto-grants-2015_09
Patent number
US09132126B2

Reaction notes

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